Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0070aep1104 | Hot topics (including COVID-19) | ECE2020

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

Camm Emily , Inzani Isabella , De Blasio Miles , Davies Katie , Lloyd India , Peter Wooding F. B. , Fowden Abigail , Forhead Alison

Development of the fetal hypothalamic-pituitary-adrenal (HPA) axis is important for normal maturation of the fetus and the timing of parturition. In hypothyroid fetuses, gestational length may be prolonged and maturational processes delayed, although the role of the HPA axis is unknown. This study investigated the effects of hypothyroidism before birth on the structure and function of the anterior pituitary and adrenal glands in fetal sheep near term.All...
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ea0046oc1 | (1) | UKINETS2016

Netazepide, a gastrin/CCK2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis

Boyce Malcolm , Moore Andrew , Parsons Bryony , Lloyd Katie , Sagatun Liv , Thomsen Liv , Varro Andrea , Fossmark Reidar , Waldum Helge , Pritchard David M

Introduction: In a two-centre, 12-week, open trial in 16 patients with autoimmune chronic atrophic gastritis, hypergastrinaemia, multiple type 1 gastric neuroendocrine tumours (NETs), and raised circulating CgA, the gastrin/CCK2 receptor antagonist (CCK2RA), netazepide, reduced the tumour number and size, and normalised CgA.Aim(s): To treat those patients with netazepide for longer, and to identify new biomarkers.Materials and meth...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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